Bibliography of Zinc Research and Publications:
Evidence supporting the recommendation for zinc and ORS
- Fischer Walker CL and Black RE (2010). Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol; 39(1): i63–i69.
- Munos M, Fischer Walker CL, Black RE (2010). The effect of Oral Rehydration Solution and Recommended Home Fluids on diarrhea mortality. Int J Epidemiol; 39(1):i75-i87.
- Santosham M, Chandran A, Fitzwater S, Fischer Walker C et al. (2010). Progress and barriers for the control of diarrhoeal disease. Lancet; 376(9734):63-67.
- Fischer Walker CL, Fontaine O, Young MW, and Black RE (2009). Zinc and low osmolarity oral rehydration salts for diarrhoea: a renewed call to action. Bull World Health Organ;87 (10):780–786.
- Bhandari N, Mazumder S, Taneja S, Dube B, Agarwal RC, Mahalanabis D, Fontaine O, Black RE, Bhan MK (2008). Effectiveness of Zinc Supplementation+ORS vs ORS Alone as a Treatment for Acute Diarrhea in a Primary Care Setting-Cluster Randomized Trial. Pediatrics: 121:5
- Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, Vaughan JP (2002). Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ: 325.
- Strand TA and Mathisen M (2005). Zinc and childhood infections: From the laboratory to new treatment recommendations. Norsk Epidemiologi; 15(2): 151-157.
Large-scale effectiveness studies demonstrating the effect of zinc for diarrhea treatment
- Mazumder S, Taneja S, Bhandari N, Dube B, et al (2010). Effectiveness of zinc supplementation plus oral rehydration salts for diarrhoea in infants aged less than 6 months in Haryana state, India. Bull World Health Organ;88(10):754–760.
- Bhandari N, Mazumder S, Taneja S, Dube B, et al (2008). Effectiveness of Zinc Supplementation Plus Oral Rehydration Salts Compared With Oral Rehydration Salts Alone as a Treatment for Acute Diarrhea in a Primary Care Setting: A Cluster Randomnized Trial. Pediatrics; 121(5): e1271-e1285.
- Baqui AH, Black RE, El Arifeen S, Yunus M, et al (2002). Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ;325(7372):1059.
Efficacy Studies of Zinc for the Treatment of Diarrhea
- Alam DS, Yunus M, El Arifeen S, Chowdury HR, et al (2011). Zinc Treatment for 5 or 10 Days Is Equally Efficacious in Preventing Diarrhea in the Subsequent 3 Months among Bangladeshi Children. J. Nutr. 141: 312–315.
- Solomons NW, Romero-Abal M-E, Weiss G, Michalke B and K Schumann K (2011). Solomons NW et al. (2011) Bioavailability of zinc from NutriSet zinc tablets compared with aqueous zinc sulfate. European Journal of Clinical Nutrition: 65, 125–131
- Larson CP, Nasrin D, Saha A, Chowdhury MI, and Qadri F (2010). The added benefit of zinc supplementation after zinc treatment of acute childhood diarrhoea: a randomized, double-blind field trial. Trop Med Int Health;15(6):754-761.
- Lazzerini M (2008). Zinc Supplements for Severe Cholera. BMJ; 336(7638):227-228
- Roy SK, Hossain MJ, Khatun W, Chakraborty B, et al (2008). Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial. BMJ;336(7638):266-268.
- Lazzerini M, Ronfani L (2008). Oral Zinc for treating diarrhoea in children (Review). The Chochrane Library; Issue 3.
- Roy SK, Tomkins AM, Akramuzzaman SM, Chakraborty B, et al (2007). Impact of Zinc Supplementation on Subsequent Morbidity and Growth in Bangladeshi Children With Persistent Diarrhoea. J Health Popul Nutr;25(1):67-74.
- Sazawal S, Black RE, Ramsan M, Chwaya HM, et al (2007). Effect of zinc supplementation on mortality in children aged 1–48 months: a community-based randomised placebo controlled trial. Lancet; 369 (9565): 927–934.
- Fischer Walker CL, Bhutta ZA, Bhandari N, Teka T, et al (2006). Zinc Supplementation for the Treatment of Diarrhea in Infants in Pakistan, India and Ethiopia. J Pediatr Gastroenterol Nutr;43(3):357-363.
- Bhandari N, Bahl R, Taneja S, Strand T, Mølbak K, Ulvik RJ, Sommerfelt H and Bhan MK (2002).Substantial Reduction in Severe Diarrheal Morbidity by Daily Zinc Supplementation in Young North Indian Children. Pediatrics: 109;6
- Strand TA, Chandyo RK, Bahl R, Sharma PR, et al (2002). Effectiveness and Efficacy of Zinc for the Treatment of Acute Diarrhea in Young Children. Pediatrics;109(5):898-903.
- Bhutta ZA, Bird SM, Black RE, Brown KH, et al (2000). Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr;72(6):1516–1522.
General Zinc deficiency
- Shrimpton R, Gross R, Darnton-Hill I and Young M (2005). Zinc deficiency: what are the most appropriate interventions? BMJ;330(7487):347-349.
- Fischer Walker CL and Black RE (2004). Zinc and the Risk for Infectious Disease. Annu Rev Nutr; 24:255–75.
- International Zinc Nutrition Consultative Group (IZiNCG) (2004). Assessment of the risk of zinc deficiency in populations and options for its control. Hotz C and Brown KH, eds. Food Nutr Bull; 25: S91-S203.
- Black RE (2003). Zinc Deficiency, Infectious Disease and Mortality in the Developing World. J Nutr; 133: 1485S–1489S.
- Penny M (1999). The Role of Zinc in Child Health. Brussels: International Zinc Association (IZA).
Zinc for the Prevention of Diarrhea and Pneumonia
- Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, et al (2007). Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised placebo-controlled trial. Lancet;370(9594):1230-39.
- Brooks WA, Santosham M, Naheed A, Goswami D, et al (2005). Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial Lancet; 366(9490): 999-1004.
- Bhutta ZA, Black RE, Brown KH, Gardner JM, et al (1999). Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr;135(6):689-97.
- Sazawal F, Black RE, Bhan MK, Jalla S, Bandhari N, Sinha A, Majumdar S (1996). Zinc Supplementation Reduces the Incidence of Persistent Diarrhea and Dysentery among Low Socioeconomic Children in India. Journal of Nutrition; 126(2):443-50.
- Yakoob MY, Theodoratou E, Jabeen A, Imdad A, Eisele TP, Joy Ferguson J, Jhass A, Rudan I, Campbell H, Black RE, Bhutta ZA (2011). Preventive zinc supplementation in developing countries- impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health 11(Suppl 3):S23
Zinc and ORS for Diarrhea Treatment: Program Design and Implementation
- Wilson SE, Ouédraogo CT, Prince L, Ouédraogo A, Hess SY, et al. (2012). Caregiver Recognition of Childhood Diarrhea, Care Seeking Behaviors and Home Treatment Practices in Rural Burkina Faso- A Cross-Sectional Survey. PLoS ONE: 7(3).
- Larson CP, Koehlmoos TP, Sack DA, and the Scaling Up of Zinc for Young Children (SUZY) Project Team (2011). Scaling up zinc treatment of childhood diarrhoea in Bangladesh: theoretical and practical considerations guiding the SUZY Project. Health Policy and Plan.;1-13.
- Wang W, MacDonald VM, Paudel M, and Banke KK (2011). National Scale-up of Zinc Promotion in Nepal: Results from a Post-project Population-based Survey. J Health Popul Nutr;29(3):207-217.
- Shamima A & Larson CP (2010). Willingness to pay for zinc treatment of childhood diarrhoea in a rural population of Bangladesh. Health Policy and Planning; 25:230–236
- Winch PJ, Doumbia S, Kante M, Male AD, et al (2008). Differential Community Response to Introduction of Zinc for Childhood Diarrhea and Combination Therapy in Southern Mali. J Nutr;138(3):642-645.
- Winch PJ, Gilroy KE, Doumbia S, Patterson AE, et al (2008). Operational Issues and Trends Associated with the Pilot Introduction of Zinc for Childhood Diarrhoea in Bougoni District, Mali. J Health Popul Nutr;26(2):151-162.
- Winch PJ, Gilroy EK, and Fischer Walker CL (2008). Effect of HIV.AIDS and Malaria on the Context for Introduction of Zinc Treatment and Low-osmolarity ORS for Childhood Diarrhoea. J HEALTH POPUL NUTR 2008: 26(1):1-11
- Ellis AA, Winch P, Daoub Z, Gilroy KE, and Swedberg E (2007). Home management of childhood diarrhoea in southern Mali—Implications for the introduction of zinc treatment. J Soc Sci Med;64(3):701-12.
- Winch PJ, Gilroy KE, Doumbia S, Patterson AE, et al (2006). Prescription and Administration of a 14-Day Regiment of Zinc Treatment for Childhood Diarrhea in Mali. Am J Trop Med Hyg;74(5):880–883.
- Gilroy K, Kuszmerski N and Winch P (2005). Lessons learned in a pilot introduction of zinc treatment for childhood diarrhea in Bougouni District, Mali. Washington, DC: Office of Health, Infectious Diseases and Nutrition, Global Health Bureau, United States Agency for International Development (USAID).
- Baqui AH, Black RE, El Arifeen S, Yunus M, et al (2004). Zinc Therapy for Diarrhoea Increased the Use of Oral Rehydration Therapy and Reduced the Use of Antibiotics in Bangladeshi Children. J Health Popul Nutr;22(4):440-442.
Monitoring and Evaluation
- Fischer Walker CL, Friberg IK, Binkin N, Young M, Walker N, et al. (2011). Scaling Up Diarrhea Prevention and Treatment Interventions: A Lives Saved Tool Analysis. PLoS Med 8(3)
- Larson CP, Saha UR, and Nazrul H (2009). Impact Monitoring of the National Scale Up of Zinc Treatment for Childhood Diarrhea in Bangladesh: Repeat Ecologic Surveys. PLoS Med; 6(11): e1000175.
- Gregorioa GV, Dansa LF, Corderob CP, Panelo CA (2007). Zinc supplementation reduced cost and duration of acute diarrhea in children. Journal of Clinical Epidemiology: 60 (2007) 560-566
- Harvey, P (2005) Cost-effectiveness of zinc supplementation as an adjunct treatment for childhood diarrhea. MOST The USAID Micronutrient Program
- Robberstad B, Strand TA, Black RE, and Sommerfelt H (2004). Cost-effectiveness of zinc as adjunct therapy for acute childhood diarrhoea in developing countries. Bull World Health Organ;82(7):523-31.
Frequently Asked Questions